Single Cell/Single Particle-ICP-MS

Sunday, 02 March 2025


Time:
12:30 - 3:00 PM
Place:
t.b.a.
Presenter:
Heidi Goenaga-Infante, National Measurement Laboratory, LGC. United Kingdom
Francisco Laborda, University of Zaragoza. Spain

 

Book your participation


After 20 years of the first publications on single particle ICP-MS (spICP-MS) and 10 years of its implementation in a commercial spectrometer, single particle ICP-MS can be considered a mature technique despite its continuous evolution. In this short course, we will present the fundamentals of the technique, focusing on its metrological aspects and the key issues to obtain reliable information, both detecting conventional particles and bioparticles.

The short course will also address developments of spICP-MS in recent years from different angles including the overcome of technical challenges, development of reference methodology and reference materials and improvement of existingdocumentary ISO standards. The importance of interlaboratory comparisons to assess the state-of-the-art of the technique performed by expert laboratories will also be highlighted. 

References 

  • F. Laborda; I. Abad-Alvaro; M.S. Jimenez; E. Bolea. Catching particles by atomic spectrometry: Benefits and limitations of single particle - inductively coupled plasma mass spectrometry. Spectrochim. Acta - Part B 199 106570 (2023)
  • F. Laborda; A.C. Gimenez-Ingalaturre; E. Bolea, Eduardo. Single-particle inductively coupled plasma mass spectrometry for the analysis of inorganic engineered nanoparticles: Metrological and quality issues in Analysis and Characterisation of Metal-Based Nanomaterials. Elsevier, 2021 pp. 35–67.
  • F. Laborda; A.C. Gimenez-Ingalaturre; E. Bolea; J.R. Castillo. About detectability and limits of detection in single particle inductively coupled plasma mass spectrometry.Spectrochim. Acta - Part B 169 105883 (2020) 
  • S. Cuello-Nuñez, I. Abad-Alvaro, D. Bartczak, M. E. del Castillo Busto, D. A. Ramsay. F. Pelegrino and H. Goenaga-Infante. The accurate determination of numberconcentration of inorganic nanoparticlesusing spICP-MS with the Dynamic massflowapproach. J. Anal. Atom. Spectrom. 2020, 35, 1832-9.
  • CCQM-P194: Metrology interlaboratory comparison for number concentration of colloidal gold nanoparticles(nhttps://www.bipm.org/documents/20126/57465575/CCQM-IAWG+Strategy+document+2021-2030.pdf/56c8a480-f539-0ea2-b486-7c0fee0e0c1c)
  • J. Labuda, J. Barek , Z. Gajdosechova , H. Goenaga-Infante , L. J. Johnston , Z.Mester and S. Shtykov. Analytical chemistry of engineered nanomaterials: Part 1. Scope, regulation, legislation, and metrology (IUPAC Technical Report). Pure and App. Chem., 2020, DOI: doi.org/10.1515/pac-2021-1001.

EWCPS 2025
02 - 07 March 2025 | Hybrid Conference in Berlin (Germany) & online

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